SCFβTrCP mediates stress-activated MAPK-induced Cdc25B degradation
نویسندگان
چکیده
منابع مشابه
SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.
Cdc25A, which is one of the three mammalian CDK-activating Cdc25 protein phosphatases (Cdc25A, B and C), is degraded through SCF(βTrCP)-mediated ubiquitylation following genomic insult; however, the regulation of the stability of the other two Cdc25 proteins is not well understood. Previously, we showed that Cdc25B is primarily degraded by cellular stresses that activate stress-activated MAPKs,...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2011
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.083931